The genetic factor of Periodontitis
An individual's genetic makeup may include factors which predispose to or discourage colonization by periodontopathogenic bacteria; this finding supports the hypothesis that genetic and microbiological factors both contribute to development and progression of periodontal disease.
Recent literature has shown how certain gene polymorphisms can be predisposing and/or aggravating factors for the development of forms of progressive, treatment-resistant periodontal disease, even in subjects whose oral hygiene is excellent and who present a relative scarcity of pathogenic bacterial flora.
The traditional test for assessing periodontal risk, available on the market until 2009 defined a risk profile by analysis of polymorphisms relative to IL-1α, IL-1β e IL1RN.
Biomolecular Diagnostic, in collaboration with specialized odontological centers, has demonstrated that study of these polymorphisms alone is insufficient for a complete evaluation of an individual's risk of periodontitis. The previous test, in fact, yielded a high number of false negatives and in many cases failed to explain the biological bases for the most aggressive forms of periodontal disease.
Integration of genetic studies with clinical practice permitted Biomolecular Diagnostic to develop the innovative GPS (Genetic Periodontal Screening) test, which in addition to the polymorphisms relative to IL-1 also considers those relative to other key mediators in the inflammatory process, such as IL-10, IL-6, COX-2 and VDR.
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