PerioSafe and ImplantSafe: aMMP-8 is an early risk marker for the hidden destruction of gingival, periodontal and/or peri-implant soft and hard tissue. It is often detectable before any visible clinical signs of inflammation or loss of attachment. The test can also provide evidence of the risk of a progressing destructive disease of the periodontium, which might only be proven objectively weeks or months later using a probe or X-ray.
Matrix metalloproteinases are preliminary co-factors of periodontal tissue destruction.
"aMMP-8 precedes tissue loss" - Prof. Timo Sorsa, University of Helsinki.
Diagnostic procedures, like probing depth, bleeding on probing (BOP), periodontal screening index (PSI) or X-rays reveal the physical tissue destruction and can thereby define the extent of gingivitis/mucositis or periodontitis/peri-implantitis. But their suitability as an "early warning" system is only limited.
The classic oral hygiene parameter, the "plaque index" and the "gingival index" provide data on the presence of bacterial plaque and can be used to motivate the patient to better care. But the presence of plaque does not suggest the development of tissue damage. If a patient's immunological system is robust, the plaque may not necessarily lead to periodontitis or peri-implantitis.
The microbiological or bacterial test, on the other hand, identifies the bacteria colonizing the affected sites in the case of periodontitis or peri-implantitis.